PANCREATIC CANCER SHOCKER: DRUG DOUBLES SURVIVAL!
A pill once thought to be science fiction just smashed expectations in one of the deadliest cancers, and the numbers are brutal for the old guard: Revolution Medicines says daraxonrasib nearly doubled survival in late-stage pancreatic cancer, with patients living a median 13.2 months versus 6.7 months on standard chemotherapy, while cutting the risk of death by 60% and hitting every main and secondary goal in patients whose disease had already worsened after other treatment. One doctor called the results “truly transformational,” CEO Mark Goldsmith called them “practice-changing,” and the company is now racing to the FDA with a priority voucher that could speed approval by months. The drug targets RAS mutations, the engine behind about 90% of pancreatic cancers, long dubbed “undruggable,” and though a rash is a common side effect, doctors say it’s usually manageable. With pancreatic cancer still carrying a grim 13% five-year survival rate, investors piled in fast, sending Revolution’s shares up more than 30% and lifting its market value above $26 billion.
Atkins got his first guitar by making a trade with his brother, and it was arguably the best deal he ever made. Although he struggled with shyness and suffered from severe asthma—he had to sleep sitting up and often fell asleep still holding his guitar—he became an accomplished guitarist and went on to release several hit records, develop a signature line of guitars, and help create country music's "Nashville sound." What did "Mr. Guitar," as he came to be known, trade to get that first guitar?
West Virginia Day is a state holiday in
Excluding water, tea is the most widely consumed drink on the planet, drunk either hot or cold by half the world's population. The vast majority of tea sold in the West is black tea, made from fermented leaves of the Camellia sinensis plant. Generally stronger in flavor and more caffeinated than the green and oolong varieties, black tea retains its flavor for several years and has long been an article of trade, serving as a form of currency into the 19th century in what countries?
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